Welcome aboard! Our group is interested in developing computational and theoretical tools to provide fundamental insights into the mechanism of gene regulation and nanoscale self-assembly. We are interested in a wide range of exciting projects ranging from chromatin regulation via histone modifications and ATP-dependent enzymes to RNA folding and design to carbon nanotube and colloid self-assembly. Please visit the research link above for more details.

Left figure: Representative snapshots of short oligonucleosomes (chromatin fragments) obtained from Monte Carlo simulations showing their irregular zigzag morphology. The center figure shows the detailed mesoscopic model used to represent a 48-unit chromatin fiber in which the nucleosomes are modeled as rigid irregular-shaped charged objects; the dsDNA is modeled as the discretized version of the work-like chain model, and the histone tails are modeled as coarse-grained bead-chains. The surrounding figures show "cartoon" representations of chromatin segments of different lengths. See representative publications: Gaurav Arya, Qing Zhang, and Tamar Schlick, Biophys J. 91, 133 (2006) Gaurav Arya and Tamar Schlick, PNAS 103, 16236 (2006) Gaurav Arya and Tamar Schlick, J. Chem. Phys. 126, 044107 (2007)

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