Welcome aboard! Our group is interested in using computational and theoretical tools to provide fundamental insights into the mechanism of gene regulation. Specifically, we are interested in chromatin folding and regulation via histone modifications, RNA folding and design, and DNA-binding protein transport. At the same time, we are also interested in molecular engineering of therapeutics based on gene regulation principles. Please visit our research page for more details.

Left figure: Representative snapshots of short oligonucleosomes (chromatin fragments) obtained from Monte Carlo simulations showing their irregular zigzag morphology. The center figure shows the detailed mesoscopic model used to represent a 48-unit chromatin fiber in which the nucleosomes are modeled as rigid irregular-shaped charged objects; the dsDNA is modeled as the discretized version of the work-like chain model, and the histone tails are modeled as coarse-grained bead-chains. The surrounding figures show "cartoon" representations of chromatin segments of different lengths. See representative publications: Gaurav Arya, Qing Zhang, and Tamar Schlick, Biophys J. 91, 133 (2006) Gaurav Arya and Tamar Schlick, PNAS 103, 16236 (2006) Gaurav Arya and Tamar Schlick, J. Chem. Phys. 126, 044107 (2007)

Positions: Multiple openings at the graduate and postdoctoral levels are available. Please email Gaurav Arya at garya[AT]ucsd[DOT]edu if interested.